发布日期: 2025-04-24

更新日期: 2025-05-01

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2025-04-24 更新

Rotational ultrasound and photoacoustic tomography of the human body

Authors:Yang Zhang, Shuai Na, Jonathan J. Russin, Karteekeya Sastry, Li Lin, Junfu Zheng, Yilin Luo, Xin Tong, Yujin An, Peng Hu, Konstantin Maslov, Tze-Woei Tan, Charles Y. Liu, Lihong V. Wang

Imaging the human body’s morphological and angiographic information is essential for diagnosing, monitoring, and treating medical conditions. Ultrasonography performs the morphological assessment of the soft tissue based on acoustic impedance variations, whereas photoacoustic tomography (PAT) can visualize blood vessels based on intrinsic hemoglobin absorption. Three-dimensional (3D) panoramic imaging of the vasculature is generally not practical in conventional ultrasonography with limited field-of-view (FOV) probes, and PAT does not provide sufficient scattering-based soft tissue morphological contrast. Complementing each other, fast panoramic rotational ultrasound tomography (RUST) and PAT are integrated for hybrid rotational ultrasound and photoacoustic tomography (RUS-PAT), which obtains 3D ultrasound structural and PAT angiographic images of the human body quasi-simultaneously. The RUST functionality is achieved in a cost-effective manner using a single-element ultrasonic transducer for ultrasound transmission and rotating arc-shaped arrays for 3D panoramic detection. RUST is superior to conventional ultrasonography, which either has a limited FOV with a linear array or is high-cost with a hemispherical array that requires both transmission and receiving. By switching the acoustic source to a light source, the system is conveniently converted to PAT mode to acquire angiographic images in the same region. Using RUS-PAT, we have successfully imaged the human head, breast, hand, and foot with a 10 cm diameter FOV, submillimeter isotropic resolution, and 10 s imaging time for each modality. The 3D RUS-PAT is a powerful tool for high-speed, 3D, dual-contrast imaging of the human body with potential for rapid clinical translation.

成像人体形态学和血管造影信息对于诊断、监控和治疗疾病至关重要。超声基于声阻抗变化对软组织进行形态学评估，而光声断层扫描（PAT）则能基于血红蛋白的自然吸收来可视化血管。在常规超声中，使用有限视野（FOV）探针进行血管的三维（3D）全景成像通常不切实际，而PAT则不能提供足够的基于散射的软组织形态对比。相互补充的是，快速全景旋转超声断层扫描（RUST）和PAT相结合，形成混合旋转超声和光声断层扫描（RUS-PAT），几乎可以同时获得人体的3D超声结构和PAT血管造影图像。RUST功能以成本效益高的方式实现，使用单元素超声换能器进行超声传输，并旋转弧形阵列进行3D全景检测。RUST优于传统超声，传统超声视野有限使用线性阵列或成本高昂使用需要传输和接收的半球形阵列。通过切换声源为光源，系统可轻松转换为PAT模式，在同一区域获取血管造影图像。使用RUS-PAT，我们已经成功地对人体的头部、乳房、手和脚进行了成像，具有直径为10厘米的视野、亚毫米级等距分辨率和每种模式10秒的成像时间。三维RUS-PAT是一个强大的工具，用于高速、三维、双对比度的人体成像，具有快速转化为临床应用的潜力。

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Summary

本文介绍了融合超声和光声成像技术的新型成像方法——RUS-PAT（旋转超声和光声断层扫描）。该技术结合了快速全景旋转超声断层扫描（RUST）和光声断层扫描（PAT），能同时获取人体三维超声结构和光声血管造影图像。相比传统超声成像技术，RUST具有更大的视野和成本优势。RUS-PAT可快速成像人体头部、乳房、手部及脚部，展现出良好的潜力用于高速三维双对比度成像。

Key Takeaways